Inflammation. Disc Degeneration. There is a connection.
Inflammation acts as the body’s response system to harmful
stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to repair itself
before the harm was done. Wilson Family Chiropractic is always amazed at how the body takes care of itself!
Wilson Family Chiropractic sees its Millville chiropractic care as the body’s partner in healing particularly
when spine pain is an issue. Chiropractic care utilizes
many tools like spinal manipulation, exercise, and nutrition to help
the body. Melatonin is one nutritional tool that is showing value
by interrupting the inflammatory process
related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are linked to intervertebral disc degeneration. (1) IL-1 β in fact promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body controls itself down to its cellular level
via autophagy, the natural process during which the body’s
cells clean out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin increased autophagy
and reduced the degradation of the disc’s
extracellular matrix (technically indicated by a decline
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The end conclusion was that melatonin prevents
intervertebral disc degeneration by promoting autophagy. (3)
Wow. Wilson Family Chiropractic is inspired by this research to see just
how well melatonin can work for Millville back pain related
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common condition
seen at Wilson Family Chiropractic making positive news like this quite exciting. A new
study explained how melatonin could modify
the extracellular matrix of the disc remodeling process initiated
by IL-1 β. Further, melatonin decreased the
inflammatory cell collection and decreased the release of associated
inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery
that melatonin interrupted the IL-1B feedback loop, researchers
suggested that melatonin may provide
the restoration process of intervertebral discs after damage was
already present. (1) Wilson Family Chiropractic continues
following the new research on the role inflammation plays
in Millville disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The importance of melatonin in helping
to slow or stop painful conditions due to inflammation is rising.
The description of melatonin as a multitasking molecule influencing
mood, immunity, and energy among other mechanisms is quite fitting.
It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by hindering the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland produces melatonin naturally. Melatonin influences
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) activities. (1) Melatonin’s specific influence on
inflammation and disc degeneration is most attention-getting
to Wilson Family Chiropractic and our Millville back pain patients.
CONTACT Wilson Family Chiropractic
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she illustrates how The Cox® Technic
System of Spinal Pain Management handles disc
degeneration for relief of chronic low back pain in her patient.
Schedule your Millville chiropractic appointment with
Wilson Family Chiropractic now. We can talk about the role
inflammation plays in your back pain experience and how melatonin may help with the related disc